Sepsis

"Clean hands, safe care" is the theme of this year's World Hand Hygiene Day. At MSF, we know that Hand Hygiene is the simplest and best way to prevent the transmission of infections in our facilities. This collection features some lessons learned about hand hygiene and infection, prevention, & control (IPC) in MSF projects, especially in resource-constrained environments in the Sahel, and in the era of COVID-19.

World Malaria Day is April 25th. The theme for 2023 is "Zero malaria: invest, innovate, implement" and the importance of reaching marginalized populations with the tools and strategies that are currently available. This collection highlights research on this theme, especially the latter two "i's": From research on Seasonal Chemoprophylaxis (SMC) and mass drug administration (MDA), to analyzing the reach of gene mutations (HRP2) in new environments, to other interventional research topics, these articles show how innovative approaches can be successfully implemented even in the most challenging settings to fight this global public health threat.

MSF has published dozens of peer-reviewed articles that touch on humanitarianism and ethics. The articles range from rigorous peer-reviewed research on the health of humanitarian workers, to commentaries about the ethics of conducting research in conflict settings, to various approaches on how patients should be treated.

BACKGROUND

Prognostic tools for febrile illnesses are urgently required in resource-constrained community contexts. Circulating immune and endothelial activatio...

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World Hand Hygiene Day 2023

World Malaria Day 2023

Ethics

Risk stratification of childhood infection using host markers of immune and endothelial activation in Asia (Spot Sepsis): a multi-country, prospective, cohort study

Performance evaluation of the Mini-Lab, an all-in-one clinical bacteriology laboratory adapted to low-resource settings, in a district hospital in Central African Republic: a prospective descriptive study

Antibiotic resistance in the Middle East and Southern Asia: a systematic review and meta-analysis

A call to bridge the diagnostic gap: diagnostic solutions for neonatal sepsis in low- and middle-income countries

Global, regional and national trends in the burden of neonatal respiratory failure and essentials of its diagnosis and management from 1992 to 2022: A scoping review

Retrospective analysis of fungemia among children in Anka General Hospital, Nigeria, from October 2018 to November 2021: a case series

C-reactive protein and procalcitonin use in adults in low- and middle-income countries: a narrative review

Evaluation of InTray cassettes directly from blood cultures for the diagnosis of sepsis in clinical bacteriology laboratories as an alternative to classic culture media

Early warning for healthcare acquired infections in neonatal care units in a low-resource setting using routinely collected hospital data: The experience from Haiti, 2014–2018

When first line treatment of neonatal infection is not enough: blood culture and resistance patterns in neonates requiring second line antibiotic therapy in Bangui, Central African Republic

Multi-drug resistance and high mortality associated with community-acquired bloodstream infections in children in conflict-affected northwest Nigeria

Population pharmacokinetics and significant under-dosing of anti-tuberculosis medications in people with HIV and critical illness

Rectal screening displays high negative predictive value for bloodstream infection with (ESBL-producing) Gram-negative bacteria in neonates with suspected sepsis in a low-resource setting neonatal care unit

Morbidities & outcomes of a neonatal intensive care unit in a complex humanitarian conflict setting, Hajjah Yemen: 2017-2018

Negative pressure wound therapy versus standard treatment in patients with acute conflict-related extremity wounds: a pragmatic, multisite, randomised controlled trial

A nosocomial outbreak of clinical sepsis in a neonatal care unit (NCU) in Port-Au-Prince Haiti, July 2014 - September 2015

Antimicrobial-resistant infections among postpartum women at a Ugandan referral hospital

Improved Neonatal Mortality at a District Hospital in Aweil, South Sudan

Causes of pediatric mortality and case-fatality rates in eight Médecins Sans Frontières-supported hospitals in Africa

Mortality after fluid bolus in children with shock due to sepsis or severe infection: a systematic review and meta-analysis

Adult and paediatric mortality patterns in a referral hospital in Liberia 1 year after the end of the war