Kowalski M, Minka Obama B, Catho G, Dewez JE, Merglen A, et al.
2024-03-08 • eClinicalMedicine
2024-03-08 • eClinicalMedicine
BACKGROUND The burden of antimicrobial resistance (AMR) has been estimated to be the highest in sub-Saharan Africa (SSA). The current study estimated the proportion of drug-resistant...
Jindani A, Atwine D, Grint D, Bah B, Adams J, et al.
2023-09-01 • NEJM Evidence
2023-09-01 • NEJM Evidence
BACKGROUND Shorter but effective tuberculosis treatment regimens would be of value to the tuberculosis treatment community. High-dose rifampicin has been associated with more rapid a...
INTRODUCTION There is conflicting evidence and practice regarding the use of the non-nucleoside reverse transcriptase inhibitors (NNRTI) efavirenz (EFV) and nevirapine (NVP) in first...
Shroufi A, van Cutsem G, Cambiano V, Bansi-Matharu L, Duncan K, et al.
2019-08-01 • AIDS
2019-08-01 • AIDS
BACKGROUND Many individuals failing first-line antiretroviral therapy (ART) in sub-Saharan Africa never initiate second-line ART or do so after significant delay. For people on ART w...
Ajose O, Mookerjee S, Mills EJ, Boulle AM, Ford NP
2012-05-15 • AIDS
2012-05-15 • AIDS
A growing proportion of patients on antiretroviral therapy in resource-limited settings have switched to second-line regimens. We carried out a systematic review in order to summarize re...
Egger M, Sidle J, Weigel R, Geng EH, Fox MP, et al.
2011-01-01 • PLOS Medicine
2011-01-01 • PLOS Medicine
The World Health Organization estimates that in sub-Saharan Africa about 4 million HIV-infected patients had started antiretroviral therapy (ART) by the end of 2008. Loss of patients to ...
2012-10-09 • Journal of the International AIDS Society
2012-10-09 • Journal of the International AIDS Society
Though the advantages of routine virological monitoring for patients on anti-retroviral therapy have been established, cost and complexity limit its full implementation. Monitoring is im...
Motlaleng M, Edwards JK, Namboze J, Butt W, Moakofhi K, et al.
2018-04-25 • Public Health Action
2018-04-25 • Public Health Action
BACKGROUND Reliable information reporting systems ensure that all malaria cases are tested, treated and tracked to avoid further transmission. Botswana aimed to eliminate malaria by ...
Spaar A, Graber C, Dabis F, Coutsoudis A, Bachmann L, et al.
2010-06-01 • AIDS Care
2010-06-01 • AIDS Care
Expanded access to antiretroviral therapy (ART) offers opportunities to strengthen HIV prevention in resource-limited settings. We invited 27 ART programmes from urban settings in Africa...
Obopile M, Segoea G, Waniwa K, Ntebela DS, Moakofhi K, et al.
2018-04-25 • Public Health Action
2018-04-25 • Public Health Action
Setting: Larviciding has potential as a component of integrated vector management for the reduction of malaria transmission in Botswana by complementing long-lasting insecticide nets and...
Ford NP, Mofenson L, Kranzer K, Medu L, Frigati L, et al.
2010-06-19 • AIDS
2010-06-19 • AIDS
INTRODUCTION Primate studies and some observational human data have raised concern regarding an association of first-trimester efavirenz exposure with central nervous system congenit...
Moakofhi K, Edwards JK, Motlaleng M, Namboze J, Butt W, et al.
2018-04-25 • Public Health Action
2018-04-25 • Public Health Action
Background: Malaria elimination requires infection detection using quality assured diagnostics and appropriate treatment regimens. Although Botswana is moving towards malaria elimination...
