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Showing 1 - 20 of 792 Items
Showing 1 - 20 of 792 Items
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Journal Article
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Review

The effectiveness of isoniazid preventive treatment among contacts of multidrug-resistant tuberculosis: A systematic review and individual-participant meta-analysis

Martinez L, Campbell JI, Linde L, Boulahbal F, Cayla JA,  et al.
2025-09-23 • American Journal of Respiratory and Critical Care Medicine
2025-09-23 • American Journal of Respiratory and Critical Care Medicine

RATIONALE

Recent empirical research suggests isoniazid may lead to a risk reduction ...

Journal Article
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Protocol

Evaluating the diagnostic accuracy of WHO-recommended treatment decision algorithms for childhood tuberculosis using an individual person dataset: a study protocol

Olbrich L, Larsson L, Dodd P, Palmer M, Nguyen MHTN,  et al.
2025-09-17 • BMJ Open
2025-09-17 • BMJ Open

INTRODUCTION

In 2022, the WHO conditionally recommended the use of treatment decision algorithms (TDAs) for treatment decision-making in children <10 years with...

Technical Report
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Policy Brief

MSF in Karakalpakstan

MSF
2025-09-01
2025-09-01
Journal Article
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Research

Pharmacokinetics of rifampicin and isoniazid in patients with HIV–tuberculosis coinfection receiving efavirenz-based antiretroviral treatment: an ANRS12292–RIFAVIRENZ sub-study

Gelé T, Atwine D, Baudin E, Muyindike W, Mworozi K,  et al.
2025-08-29 • Journal of Antimicrobial Chemotherapy
2025-08-29 • Journal of Antimicrobial Chemotherapy

BACKGROUND

Increasing rifampicin dosing is considered a potent strategy for shortening TB treatment ...

Journal Article
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Pre-Print

Effect of smoking on drug-resistant tuberculosis treatment outcomes and exploring potential pathways: A multicountry cohort study

Romo ML, LaHood A, Stagg HR, Mitnick CD, Trevisi L,  et al.
2025-08-24 • medRxiv
2025-08-24 • medRxiv

People who smoke are at increased risk of unfavorable tuberculosis (TB) treatment outcomes compared with tho...

Journal Article
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Research

Characterizing treatment adherence trajectories in the endTB multisite cohort of drug-resistant tuberculosis patients: an application of group-based trajectory modelling

Law S, Fulcher I, Ashraf S, Bastard M, Docteur W,  et al.
2025-08-22 • Clinical Infectious Diseases
2025-08-22 • Clinical Infectious Diseases

BACKGROUND

In tuberculosis (TB) care, adherence is often assessed using a simple 80% threshold, ...

Journal Article
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Research

The frequency and incidence of QT prolongation with extended use of bedaquiline or delamanid in a large, multi-country multidrug-resistant/rifampicin-resistant tuberculosis cohort

Khan U, Rich M, Franke MF, Lachenal N, Ahmed S,  et al.
2025-08-01 • Clinical Infectious Diseases
2025-08-01 • Clinical Infectious Diseases

BACKGROUND

The 2022 World Health Organization (WHO) guidelines on multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) recommend 6 months of bedaqu...

Journal Article
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Review

Optimal dosing and duration of linezolid for the treatment of multidrug-resistant and rifampicin-resistant tuberculosis: An individual patient data meta-analysis

Kwak N, Kim JY, Han A, Berry C, Beumont M,  et al.
2025-07-17 • European Respiratory Journal
2025-07-17 • European Respiratory Journal

BACKGROUND

The optimal dosing strategy of linezolid for treating multidrug-resistant and rifampicin-resistant tuberculosis (MDR/RR-TB) remains unclear. We condu...

Journal Article
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Research

Bedaquiline, delamanid, linezolid, and clofazimine for rifampicin-resistant and fluoroquinolone-resistant tuberculosis (endTB-Q): an open-label, multicentre, stratified, non-inferiority, randomised, controlled, phase 3 trial

Guglielmetti L, Khan U, Velásquez GE, Gouillou M, Ali MH,  et al.
2025-07-16 • Lancet Respiratory Medicine
2025-07-16 • Lancet Respiratory Medicine
Journal Article
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Research

Decentralising TB diagnosis and contact management: impact on detection and preventive treatment in children

Delmas V, Vasiliu A, Tchakounté Youngui B, Ssekyanzi B, Kuate Kuate A,  et al.
2025-06-27 • International Journal of Tuberculosis and Lung Disease
2025-06-27 • International Journal of Tuberculosis and Lung Disease

BACKGROUND

The ‘CaP-TB’ project enhanced paediatric TB care through decentralized services, including screening, specimen collection, chest X-rays and implement...

Journal Article
|
Review

Clinical best practices for caring for people with expanded resistance to newer TB drugs

Nkomo T, Udwadia Z, Vambe D, van Rie A, Thi S,  et al.
2025-06-13 • IJTLD OPEN
2025-06-13 • IJTLD OPEN

BACKGROUND

Strains of Mycobacterium tuberculosis

Journal Article
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Research

Concomitant splenic tuberculosis and Epstein–Barr virus-related T-cell leukemia/lymphoma in a 28-year-old pregnant woman in South Sudan

Wild HB, Aumuller J, Kuei J, Simon M, Palm A,  et al.
2025-06-04 • American Journal of Tropical Medicine and Hygiene
2025-06-04 • American Journal of Tropical Medicine and Hygiene

This case report presents a rare instance of concomitant splenic tuberculosis (TB), Epstein–Barr virus (EBV)-related T-cell leukemia/lymphoma, and malaria in a 28-year-old pregnant wo...

Journal Article
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Research

Centrifuge-free stool processing methods for Xpert MTB/RIF Ultra tuberculosis diagnosis in children in Uganda and Zambia: an observational, prospective, diagnostic accuracy study

Lounnas M, Masama EN, Beneteau S, Kasakwa K, Kaitano R,  et al.
2025-06-01 • Lancet Microbe
2025-06-01 • Lancet Microbe

BACKGROUND

WHO recommends Xpert MTB/RIF Ultra (Ultra) for stool testing for tuberculosis diagnosis in children. Stool processing requires removal of debris and ...

Journal Article
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Research

End of treatment and 12-month post-treatment outcomes in patients treated with all-oral regimens for rifampicin-resistant tuberculosis in Ukraine: a prospective cohort study

Fardhdiani V, Trush O, Lytvynenko N, Pylypchuk S, Terleeva Y,  et al.
2025-05-23 • PLOS Global Public Health
2025-05-23 • PLOS Global Public Health

The World Health Organization has called for operational research on all-oral shorter regimens for rifampin-resistant and multidrug-resistant forms of tuberculosis (RR/MDR-TB). We fol...

Conference Material
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Abstract

Implementation of treatment-decision algorithms for children with pulmonary tuberculosis: cross-cutting lessons for operational scale-up

Armour-Marshall J, Scarpa G, Abdullahi MB, Farouk Moussa Mamane O, Fidelle Nyikayo L,  et al.
2025-05-22 • MSF Scientific Days International 2025
2025-05-22 • MSF Scientific Days International 2025
Conference Material
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Slide Presentation

Implementation of treatment-decision algorithms for children with pulmonary tuberculosis: cross-cutting lessons for operational scale-up

Armour-Marshall J, Scarpa G, Abdullahi MB, Farouk Moussa Mamane O, Fidelle Nyikayo L,  et al.
2025-05-22 • MSF Scientific Days International 2025
2025-05-22 • MSF Scientific Days International 2025
Journal Article
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Research

Body mass index trajectories and association with tuberculosis risk in a cohort of household contacts in Southern Africa

Larsson L, Calderwood CJ, Marambire ET, Held K, Banze D,  et al.
2025-04-28 • Clinical Infectious Diseases
2025-04-28 • Clinical Infectious Diseases

BACKGROUND

Studies have demonstrated an inverse log-linear relationship between body mass index (BMI) and tuberculosis incidence. However, a person’s BMI is dyn...

Journal Article
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Research

COVID-19, tuberculosis, and HIV triad: a prospective observational study in ambulatory patients in Kenya, Uganda, and South Africa

Huerga H, Gouillou M, Ohler L, Taremwa IM, Akinyi M,  et al.
2025-04-23 • PLOS Global Public Health
2025-04-23 • PLOS Global Public Health

People living with HIV (PLHIV) have an increased risk of tuberculosis (TB) and severe COVID-19. TB and COVI...

Journal Article
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Research

Enhancing tuberculosis (TB) case detection among hospitalized patients through lay health worker led screening: a before-and-after study in KwaZulu-Natal, South Africa

Bulti AB, Dumicho AY, Shigayeva A, Van Cutsem G, Steele SJ,  et al.
2025-04-23 • Scientific Reports
2025-04-23 • Scientific Reports

Tuberculosis (TB) among hospitalized patients is underdiagnosed. This study assessed systematic TB-screenin...

Journal Article
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Research

Cost analysis of the TB-PRACTECAL clinical trial on novel tuberculosis treatment regimens

Gotham D, Martin M, Barber MJ, Kazounis E, Batts C,  et al.
2025-04-23 • PLOS Global Public Health
2025-04-23 • PLOS Global Public Health

Clinical trials are considered to be the largest contributor to pharmaceutical development costs. However, public disclosure of the costs of individual clinical trials is rare. Médec...