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Collection Content

Journal Article
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Research

Risk stratification of childhood infection using host markers of immune and endothelial activation in Asia (Spot Sepsis): a multi-country, prospective, cohort study

Chandna A, Koshiaris C, Mahajan R, Ahmad RA, Van Anh DT,  et al.
2025-09-01 • Lancet Child and Adolescent Health
2025-09-01 • Lancet Child and Adolescent Health

BACKGROUND

Prognostic tools for febrile illnesses are urgently required in resource-constrained community contexts. Circulating immune and endothelial activatio...

Journal Article
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Letter

War wounds caused by explosive weapons in Gaza: data from a 2024 study by Médecins Sans Frontières

Nicolai M, Safi SSS, Casera M, Dekhili D, Hook C,  et al.
2025-07-01 • Lancet
2025-07-01 • Lancet
Journal Article
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Pre-Print

Feasibility and acceptability of menstrual underwear in a conflict and population displacement prone setting of Kalehe, Democratic Republic of the Congo

Bisimirwe C, Maombi S, Nabuki S, Mubelelwa L, Llosa AE,  et al.
2025-06-29 • Research Square
2025-06-29 • Research Square

Menstrual hygiene management remains a critical yet often neglected issue in humanitarian setting. Reusable menstrual underwear (MU) offers a potentially sustainable and discrete solu...

Conference Material
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Abstract

Newly discovered paediatric melioidosis in Mali: the tip of an African iceberg?

Lichtenegger S, Michel J, Mollo B, Sanogo A, Diawara H,  et al.
2025-05-22 • MSF Scientific Days International 2025
2025-05-22 • MSF Scientific Days International 2025
Journal Article
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Short Report

Providing emergency medical care at the Belarus-Poland border

Zadykowicz R, Kuc J, Ladomirska J, Zamatto F, Lim SY
2025-05-01 • Forced Migration Review
2025-05-01 • Forced Migration Review
Journal Article
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Research

High caseload of Scabies amongst Rohingya refugees in Cox’s Bazar, Bangladesh: a retrospective analysis of the epidemiological and clinical characteristics of cases, July 2022 to November 2023

Alhaffar BA, Islam S, Hoq MI, Das A, Shibloo SM,  et al.
2025-04-09 • PLOS Global Public Health
2025-04-09 • PLOS Global Public Health

Scabies is a dermatological parasitic infestation prevalent in many regions worldwide. Classified as a neglected disease by World Health Organization (WHO) since 2017, it is often ass...

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Adapting essential care programs to Covid-19 pandemic times
Adapting essential care programs to Covid-19 pandemic times
As the ongoing Covid-19 pandemic grips the world, one of its most devastating indirect effects is the disruption to medical services for preventing and treating other life-threatening diseases—especially in countries with already-fragile health systems. For MSF and other global health actors this means not only responding to Covid-19 directly but also assessing its impact on other essential care and then adapting programs so they can keep serving patients despite the enormous obstacles. In this Collection you will find a selection of published articles and conference content from this year’s MSF Scientific Days 2021 conference content, encompassing a range of approaches, settings and medical challenges—from malaria, TB and HIV/AIDS prevention and care to digital health promotion and sexual and reproductive health.
TB-PRACTECAL Trial—Evidence for a shorter, safer, more effective treatment for drug-resistant tuberculosis
TB-PRACTECAL Trial—Evidence for a shorter, safer, more effect...
Drug-resistant tuberculosis (DR-TB) remains an especially deadly form of the ancient scourge of TB, while current treatments are long, toxic, and ineffective for half of all patients. Aiming to change this unacceptable status quo, in the mid-2010’s MSF and partners launched three clinical trials to test novel regimens containing the first new TB drugs in decades. On 22 December 2022 the New England Journal of Medicine published findings from TB-PRACTECAL, a three-country randomized controlled trial, showing that a shorter regimen is safer and cured 89% of DR-TB patients, compared with 52% on the standard of care. These findings have already been incorporated into the World Health Organization’s new TB treatment guidelines. A separate study shows that the new regimen is also more cost-effective. Alongside these results the content collection linked below highlights other aspects of the trial, from community engagement strategies that helped shape TB-PRACTECAL to setbacks arising from the Covid-19 pandemic. It also examines urgent challenges in scaling up access to these life-saving drugs, including affordability and patent barriers.
Snake envenoming: a neglected crisis
Snake envenoming: a neglected crisis

Every year 2 million or more people fall victim to snakebite envenoming, mostly in poor, rural communities of Africa, Asia and Latin America. Between 83,000—138,000 of them die, while hundreds of thousands more suffer debilitating long-term complications or disabilities.


Although some antivenom medicines are highly effective when used promptly and appropriately, many snakebite victims get no treatment at all. Those who do may receive antivenoms which don’t work against the type of snake that bit them, or were not rigorously tested for safety and effectiveness.


To mark World Snakebite Awareness Day on September 19th, the Collection linked below brings together recent MSF work on this highly neglected disease. Several articles and conference presentations help fill evidence gaps on the burden of disease and its impacts or on treatment outcomes with specific antivenoms in specific regions. Others examine how to tackle the formidable challenges of availability and affordability, the absence of regulatory oversight for making, testing and registering antivenoms, and the anemic R&D pipeline for new products—all of which impede access for patients to safe, effective treatment tailored to local snake species.

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